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Old 03-29-2012, 01:00 PM   #1
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Lightbulb MIT Cures All Viruses

DRACO: Death to the Virus

Imagine a future where no one comes down with a cold, ever. Where no chicken pocks or measles mar youthful faces. No yearly flu going around. A future where the thought of someone having a viral infection will be considered barbaric, a thing that only happens in the poorest corners of the world. And soon enough, not even there. A world where AIDS is a thing of the past, having been wiped from humanity's memory, become little more than a fairy tale, the time when viruses tyrannized humanity unchecked like barbarian hordes.

Well, we officially live in the future.

MIT, the Massachusetts Institute of Technology, is the leading technical university in the world. It seems like every other week there's news from MIT about some important new discovery they've produced.

But this one takes the cake.

MIT look at genetic aspects of a virus that seldom or never change. Some parts of all viruses can change quite rapidly, but others are locked in place. And it has to be something that human cells don't have at all.

And they found one. And they exploited it, such that any time a virus tries to replicate, this drug called DRACO immediately causes cell death. The cell the virus had tried to hijack to create more copies of itself (and would have killed in the process anyway), now self-destructs and short-circuits the viral replication process.

The virus, without the protection of being inside one of your cells, is then attacked by your own immune system and destroyed. This is a game changer. This is a nuclear bomb in the war against viruses. We can truly wipe them out once and for all.

Now we just have to take down bacteria :P

So how long until we see this drug on the market? Firstly, it probably won't be incredibly expensive, because it's not a niche drug. Everyone will take this drug, everyone on the planet. It will be about as ubiquitous as aspirin, and because it's a piece of genetic code and not some chemical, it will have no effect on your body at all.

They've tested the drug on 16 very different kinds of virus families in mice, and found broad-spectrum effectiveness. They've done tons of mice trials. But it's going to take at least 10 years to get the drug into our hands! Because the FDA demands that tons of animal and human trials be performed before they'll allow a drug onto the market. That's a pity, because this drug could save many lives between then and now.

Here's the full article: http://www.process.org/discept/2011/...-to-the-virus/
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Old 03-29-2012, 01:19 PM   #2
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DRACO also sounds like it's one step away from being a biological weapon.
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Old 03-29-2012, 01:33 PM   #3
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Draco's just an acronym:
Quote:
In a paper published 27 July [1], researchers from MIT reported successful tests in mice with a new drug that holds the promise of being a cure to all viruses. The drug, DRACO (Double-stranded RNA Activated Caspase Oligomerizer), works as a “broad-spectrum” antiviral, killing virus-hijacked cells by targeting double-stranded RNA produced in the viral replication process. DRACO proved successful against all 15 viruses tested “including rhinoviruses that cause the common cold, H1N1 influenza, a stomach virus, a polio virus, dengue fever and several other types of hemorrhagic fever.” [2]

We may expect results from cell trials against AIDS within the next 12 months.
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Old 03-29-2012, 01:36 PM   #4
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Originally Posted by Anenome View Post
Draco's just an acronym:
Really? I never would have guessed after having read the article.
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Old 03-29-2012, 01:37 PM   #5
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Wow a cure for my herpes and hepatitis in one go.
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Old 03-29-2012, 02:01 PM   #6
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Really? I never would have guessed after having read the article.
No thread would be complete without you injecting unnecessary sarcasm into it, apparently
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Old 03-29-2012, 02:04 PM   #7
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I'm still gonna die. I need organs goddamn it! 2020 can't come fast enough.
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Old 03-29-2012, 02:08 PM   #8
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I'm still gonna die. I need organs goddamn it! 2020 can't come fast enough.
3D Bio-printer to create arteries and organs

Building artificial organs using 'biological Legos'

Patients receive tailor-made urethras grown in a lab

Researchers grow laboratory-engineered miniature human livers

Scaffolding to help mend a broken heart
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Old 03-29-2012, 02:11 PM   #9
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That tech is still many years away. By my calculations and research I have come to the conclusion that by 2020 I will see if the creation of organs can be done withing my lifetime.

But I do sure hope Meusli can get rid of his herpes though. (that whore!)
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Old 03-29-2012, 02:22 PM   #10
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DRACO also sounds like it's one step away from being a biological weapon.
If you mean the ability to use, instead of part of genetic code from a virus, part of genetic code of a human being to kill humans instead of virus. Then, I agree.

It would be even worse if they could use part of the human DNA that affects only a certain group of people, a ethnicity, sex, or something. It could wipe out all humans with a certain genetic code.

Or, it could be used to wipe major plagues, insects and others.


Either way, I sure hope they can't turn it in a weapon of mass killing.
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Old 03-29-2012, 02:25 PM   #11
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That tech is still many years away. By my calculations and research I have come to the conclusion that by 2020 I will see if the creation of organs can be done withing my lifetime.

But I do sure hope Meusli can get rid of his herpes though. (that whore!)
Lol, genetic burn!

Seriously tho, if I were you, I'd find some of these promising studies, get in touch with scientists, and make sure I was in the clinical human trials at some point.
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Old 03-29-2012, 02:40 PM   #12
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I'd have to move FAAARRRR away with my millionaire money...oh wait.
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Old 03-29-2012, 03:04 PM   #13
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Didn't you say before that you figure you have 8 years to live. That's cutting it pretty close :P
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Old 03-29-2012, 03:18 PM   #14
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I hope it works out! We need more good news like this.
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Old 03-29-2012, 04:03 PM   #15
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Didn't you say before that you figure you have 8 years to live. That's cutting it pretty close :P
Meh I rather not die on an empty stomach!
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Old 03-29-2012, 05:06 PM   #16
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People give the FDA a lot of grief about the testing they require, but I'd rather this go through that testing before we find out that it makes healthy cells self destruct when replicating for some reason.

This does sound really exciting though. Too bad we can't just take a "kill them all" approach with bacteria because of the symbiotic relationships they have with our bodies.
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Old 03-29-2012, 05:09 PM   #17
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This does sound really exciting though. Too bad we can't just take a "kill them all" approach with bacteria because of the symbiotic relationships they have with our bodies.
Sure you can, just repopulate with good bacteria after you've wiped out the bacterial infection. Same thing that happens when people take antibiotics--you eat some unpasteurized yogurt after it's all over and you're back in the saddle.

I never thought viruses would be an easier target than bacteria tho >_>
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Old 03-29-2012, 05:57 PM   #18
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Sure you can, just repopulate with good bacteria after you've wiped out the bacterial infection. Same thing that happens when people take antibiotics--you eat some unpasteurized yogurt after it's all over and you're back in the saddle.

I never thought viruses would be an easier target than bacteria tho >_>
Bacteria has been around longer than us...so no surprise here.
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Old 03-29-2012, 06:14 PM   #19
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That's actually rather brilliant. Both, in terms of idea and the execution of it. Ten years seems a bit excessive, though.

Is there a chance for them to market it to other countries which require less...um...stringent testing?
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Old 03-29-2012, 06:53 PM   #20
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I never thought viruses would be an easier target than bacteria tho >_>
It makes sense if you think about it. We have a lot more in common with bacteria than viruses, so many of the things that would damage bacteria would also damage our cells. The viruses are the easier target because they need our cells to replicate and have more differences when compared to our cells. Which is exactly what they are exploiting with this drug. It just took time for the science to catch up and someone to come up with an elegant solution.

Of course we are getting ahead of ourselves since their hasn't been any human testing. Plenty of things look good in mice and then have issues when scaled up to monkeys and humans.

It was sad to read the interview that you posted and to see the struggles with funding. Big Pharma is not interested in this because it would not be a huge money maker. I bet he wouldn't have any problem getting funding if he had a breakthrough with a better boner pill.
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